Benoit Viollet Selected Research

Adenosine Monophosphate (AMP)

1/2021	AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro.
7/2020	Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice.
12/2013	Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform.
1/2012	Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway.
11/2011	AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells.
10/2011	AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.
5/2011	Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice.
2/2011	Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway.
5/2009	Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
11/2008	AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice.

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Benoit Viollet Research Topics

Disease

30	Neoplasms (Cancer) 01/2022 - 07/2006
21	Insulin Resistance 01/2022 - 01/2003
16	Obesity 01/2020 - 07/2004
16	Inflammation (Inflammations) 10/2019 - 03/2009
10	Hypoxia (Hypoxemia) 10/2021 - 07/2006
10	Type 2 Diabetes Mellitus (MODY) 10/2019 - 02/2006
7	Body Weight (Weight, Body) 01/2022 - 11/2010
6	Ischemia 06/2013 - 12/2006
5	Starvation 01/2022 - 11/2009
5	Hypertrophy 01/2018 - 09/2004
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 11/2010
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 08/2008
4	Heart Failure 08/2016 - 10/2011
3	Carcinogenesis 01/2021 - 01/2018
3	Hepatocellular Carcinoma (Hepatoma) 07/2020 - 12/2006
3	Hypertension (High Blood Pressure) 12/2018 - 05/2011
3	Fatty Liver 02/2018 - 03/2009
3	Metabolic Diseases (Metabolic Disease) 01/2018 - 05/2017
3	Cardiomegaly (Heart Hypertrophy) 01/2018 - 08/2008
3	Lung Injury 01/2016 - 05/2011
3	Hyperglycemia 07/2010 - 05/2006
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2022 - 03/2012
2	Acidosis 01/2021 - 06/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2020
2	Atherosclerosis 12/2020 - 01/2015
2	Hypoglycemia (Reactive Hypoglycemia) 11/2020 - 04/2015
2	Non-alcoholic Fatty Liver Disease 07/2020 - 01/2018
2	Fibrosis (Cirrhosis) 07/2020 - 11/2008
2	Left Ventricular Dysfunction 08/2016 - 12/2013
2	Diabetes Mellitus 08/2016 - 02/2013
2	Anemia 09/2014 - 08/2010
2	Splenomegaly 09/2014 - 01/2011
2	Sepsis (Septicemia) 12/2013 - 05/2010
2	Myocardial Ischemia (Ischemic Heart Diseases) 06/2013 - 12/2007
2	Weight Loss (Weight Reduction) 03/2011 - 07/2004
2	Thrombosis (Thrombus) 09/2010 - 05/2010
2	Hypersensitivity (Allergy) 04/2008 - 06/2007
2	Ischemic Contracture 06/2007 - 12/2006
1	Infertility (Sterility) 01/2022
1	Disease Progression 01/2022
1	Atrial Fibrillation 01/2022
1	Adenocarcinoma of Lung 01/2022

Drug/Important Bio-Agent (IBA)

43	AMP-Activated Protein KinasesIBA 01/2022 - 01/2003
27	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 09/2004
23	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 02/2006
18	Insulin (Novolin)FDA Link 10/2021 - 05/2006
18	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2004
12	Adenosine Monophosphate (AMP)IBA 01/2021 - 09/2004
9	AICA ribonucleotide (ZMP)IBA 01/2017 - 02/2007
8	LipidsIBA 12/2020 - 01/2009
7	Phosphotransferases (Kinase)IBA 01/2021 - 08/2008
7	Pharmaceutical PreparationsIBA 10/2019 - 04/2012
6	Protein Kinases (Protein Kinase)IBA 07/2020 - 11/2007
6	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 05/2010
6	Protein Isoforms (Isoforms)IBA 10/2018 - 12/2006
4	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2021 - 05/2009
4	LipopolysaccharidesIBA 10/2021 - 05/2010
4	Interleukin-6 (Interleukin 6)IBA 12/2018 - 01/2015
4	CytokinesIBA 12/2018 - 05/2011
4	Oxygen (Dioxygen)IBA 10/2018 - 07/2006
4	EnzymesIBA 11/2015 - 07/2004
4	Adenosine Triphosphate (ATP)IBA 11/2015 - 12/2006
4	TOR Serine-Threonine KinasesIBA 01/2014 - 11/2010
3	GlycogenIBA 01/2020 - 12/2006
3	BiguanidesIBA 01/2019 - 11/2010
3	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019 - 09/2012
3	ResveratrolIBA 01/2016 - 08/2008
3	Nicotine FDA Link 04/2015 - 01/2012
3	Peptide Elongation Factor 2 (EF-2)IBA 06/2013 - 02/2007
3	AdiponectinIBA 06/2011 - 03/2009
2	GSK621IBA 01/2022 - 06/2015
2	4- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrileIBA 12/2020 - 01/2015
2	Hormones (Hormone)IBA 11/2020 - 03/2011
2	Glucagon (Glukagon)FDA Link 01/2020 - 04/2015
2	Adenylate KinaseIBA 01/2020 - 04/2012
2	Interleukin-23 (Interleukin 23)IBA 01/2019 - 01/2016
2	Angiotensin IIIBA 01/2019 - 12/2018
2	CalcineurinIBA 01/2018 - 08/2008
2	LigandsIBA 08/2016 - 01/2015
2	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2016 - 03/2011
2	Lactic Acid (Lactate)FDA LinkGeneric 05/2015 - 12/2006
2	Nonesterified Fatty Acids (NEFA)IBA 04/2015 - 05/2012
2	Sirtuin 1IBA 03/2015 - 03/2010
2	Antineoplastic Agents (Antineoplastics)IBA 01/2015 - 01/2014
2	AntigensIBA 01/2015 - 04/2008
2	p38 Mitogen-Activated Protein KinasesIBA 09/2014 - 12/2007
2	AntioxidantsIBA 09/2014 - 05/2009
2	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 06/2013 - 06/2007
2	Adenosine Triphosphatases (ATPase)IBA 07/2012 - 06/2007
2	Triglycerides (Triacylglycerol)IBA 05/2012 - 11/2010
2	LeptinIBA 05/2012 - 08/2007
2	Blood Glucose (Blood Sugar)IBA 01/2012 - 01/2009
2	Transcription Factors (Transcription Factor)IBA 10/2011 - 12/2007
2	Acetyl-CoA CarboxylaseIBA 09/2011 - 12/2006
2	IronIBA 09/2011 - 01/2011
2	acadesineIBA 10/2010 - 05/2010
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2022
1	Dextrans (Dextran)FDA Link 01/2022

Therapy/Procedure

4	Therapeutics 01/2018 - 01/2009
1	Immunotherapy 01/2022